CRISPR/Cas genome editing system provided us unmatched power to install desired modification in a target genome. A plethora of CRISPR/Cas-derived tools have been developed for basic and applied research. This rapid advancement has been possible by exploiting the natural diversity of the CRISPR system coupled with protein engineering. The CRISPR-Cas toolbox offers diverse array of functionalities, including but not limited to targeted gene knockout, gene activation and repression, epigenome editing, single-base alteration, and precise insertion/deletion/replacement with either HDR or prime editing. An overview of the available CRISPR-Cas-derived tools and their mode of action and potential application will be discussed.