To further increase food production to keep pace with the ever-increasing human population, genetic improvement of crop plants is essential. However, this has to be achieved in the face of prevalent climate change with continuous rising of day/night temperature. Thus, it is desired that we develop high-yielding but climate resilient crop varieties using new plant breeding techniques. Genome or gene editing mediated by the CRISPR-Cas system has emerged as a new plant breeding tool with enormous applications in agriculture. For developing climate resilient crops, multiple traits need to be simultaneously introduced. Genome editing is particularly useful to develop these traits through multiplex gene editing by combining allelic diversity from diverse germplasm sources like crop wild relatives and land races directly into the elite crop genotypes. However, greater attention is needed to expedite the process of field testing of the genome edited events in target environments, followed by varietal development with breeders’ engagement both from public and private sector. Major emphasis is required for combining field stress tolerance with yield enhancement related traits such as improved photosynthesis, enhanced nutrient acquisition and natural resources use efficiency. A strong viable partnership across academia and industry will further help realise the full potential of this powerful technology for sustainable agriculture.