Late blight, caused by the oomycete Phytophthora infestans (Mont.) de Bary has historically been an important disease of potatoes and still continues to be the main biotic constraint for potato production. Management of late blight through host resistance will remain the most environmentally and economically preferred option globally despite the fact that none of the variety could sustain the blight onslaught for more than 5-7 years. Indian blight resistance breeding programme is not an exception. Breeding efforts using host resistance derived from S. demissum, a Mexican hexaploid species possessing both major and minor genes led to development and release of several resistant varieties viz. Kufri Jyoti, Kufri Khasigaro, Kufri Naveen, Kufri Jeevan, Kufri Neela and Kufri Muhtu. Of these, Kufri Jyoti became popular in all the hill regions. However, due to development of matching virulences, the breakdown of major gene resistance in Kufri Jyoti in mid seventies necessitated use of genes providing field resistance. Attempts are also being made to pyramid ‘R’ genes through Marker Assisted Selection (MAS) and a variety Kufri Karan has recently released possessing multiple disease resistance. Somatic hybrids with moderate levels of resistance to foliage blight have been identified for in situ hybridization in potato breeding. Besides conventional and marker assisted breeding, efforts are on to integrate resistance genes in commercial cultivars of potato through transgenic/molecular approach. A resistance gene effective against most known strains of blight has been identified from a wild relative of the potato, Solanum bulbocastanum, and introduced by genetic engineering into cultivated cultivar Katahdin. The RB-transgenic elite Katahdin line SP951 used for introgression breeding was obtained from University of Wisconsin, Madison, USA through the collaboration of India - USAID - ABSP II. The SP951 line was used to introgress the RB based resistance in two Indian commercial potato cultivars Kufri Jyoti and Kufri Bahar through conventional breeding. The F₁ hybrids were characterized molecularly for the integration of RB gene and back bone analysis of hybrid clones was performed. Introgression of RB gene in Indian popular potato cultivars has demonstrated enhanced late blight resistance and generation of valuable genetic material for resistance breeding. On the basis of late blight resistance, tuber characters and other agronomic traits; selected five Kufri Jyoti hybrids (KJ-16, KJ-21, KJ-65, KJ66, and KJ-77) for temperate highlands. Out of these selected hybrids, marker and plasmid free KJ66 line has been taken up for biosafety trials. Approaches being followed in India for managing late blight of potato through host resistance will be discussed.