Pratima Srivastava's Biography
Pratima Srivastava, Vice President, Aragen Life Sciences, India
Dr Pratima Srivastava, M. Sc. Ph.D., Currently a Vice President and Head – Drug Metabolism and Pharmacokinetics, Aragen Lifesciences, Hyderabad, India. She has Research, Teaching and Management experience of 15 years in Druggability attributes of small and large molecules and Pharmacogenomics, in the field of Drug Discovery and Development in varied disease areas across Academia, Pharma and CRO functions. Innovation in Molecular Biology and Biochemistry of malarial parasites with reference to acquisition of drug resistance, elucidation of the maiden novel heme degrading pathway in malarial parasites and its implication in the development of resistant reversal agents.
Appeared in the Dec 2017 issue of Biospectrum: The Business of Bio and Health Sciences as Women Achievers: Walking with a Purpose; Recipient of INSA Young Scientist Award; ISCA Young Scientist Award; International Union of Biochemistry and Molecular Biology Young Scientist Award; Council of Science and Technology Young Scientist Award; Prof B.K. Bacchawat Young Scientist Award; IIIrd position in University in Graduation; 71-International Papers, 28-International Patents.
She is Owner of DMPK group in LinkedIn having close to 7500 connections in the field of DMPK, Bioequivalence, Biowaiver worldwide. Visiting Scientist in Univ of Health Science Centre, San Antonio, Texas and Roswell Park Cancer Institute, Buffalo, NY, USA working on Pharmacogenomics of anticancer drugs and the interaction of p53 and ER.
Major Contributions
- In Pharmacogenomic: SNP found in the Indian population in drug metabolizing genes. Identification of the SNP responsible for Adverse drug reactions, Onset of disease; Biomarkers identification and its correlation with pharmacokinetics.
- Molecular Biology (Oncology): Demarcation of the Estrogen receptor positive and negative breast cancer as well as screening protocols towards the development of new anticancer drugs
- Alternative to Animals Models
- Maiden Innovative search for HEME Degradation Pathway in plasmodium. The pathway has been for the first time, included by Prof. Hagai Ginsburg in the Malaria Parasite Metabolic Pathways Hemoglobin digestion and Ferriprotoporphyrin IX Polymerization (http://sites.huji.ac.il/malaria/redox/html). ü It has also secured its place in the “Innovative India” edited by Prof. L.K.Sharma and Seema Sharma in the chapter entitled, “The challenge of malaria control” –2000.