Optimization, Scale-up and Solutions: Lessons Learned
Shekhar M Gaikwad, Application Engineer, Corning, India

Notable development on chemical reactions and processes under continuous flow has attracted the attention of the pharmaceutical and chemical industries.

The important question to answer is – what is the best optimized parameter? Is it minimal residence time or 100% conversion, optimum selectivity, energy saving, or a business case with minimal payback period, and finally is it a combination of it all? Through this presentation, we will try and answer these questions and aim to chart a course from lab to production.

Similarly, only optimization is not sufficient to decide from moving to production. In order to deliver successful scale-up operations, we must give equal importance to choice and the selection of flow reactors, with a significant importance to upstream and downstream equipment like dosing lines, gas handling, precise utility control, good quality raw materials, and the appropriate quenching method.

Continuous flow chemistry is often looked to as a simple concept on paper. However, scientists with significant flow chemistry experience face multiple challenges. But how do we overcome these challenges?

Through this presentation, we will identify key preparations while moving from lab to production, highlighting relevant risks and their subsequent mitigation strategies to ensure a successful scale up.

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